Saturday, August 27, 2016

Important message for Canadian Health Minister Jane Philpott!


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Thursday, August 18, 2016

A Cancer cure worth understanding.

Here is another Cancer cure worth understanding. Cancer cures are now becoming common place and I intend to find them and show them to you, dear readers.

Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions

Nature Nanotechnology
 
 
doi:10.1038/nnano.2016.137
Received
 
Accepted
 
Published online
 
Oxygen-depleted hypoxic regions in the tumour are generally resistant to therapies1. Although nanocarriers have been used to deliver drugs, the targeting ratios have been very low. Here, we show that the magneto-aerotactic migration behaviour2 of magnetotactic bacteria3Magnetococcus marinus strain MC-1 (ref. 4), can be used to transport drug-loaded nanoliposomes into hypoxic regions of the tumour. In their natural environment, MC-1 cells, each containing a chain of magnetic iron-oxide nanocrystals5, tend to swim along local magnetic field lines and towards low oxygen concentrations6 based on a two-state aerotactic sensing system2. We show that when MC-1 cells bearing covalently bound drug-containing nanoliposomes were injected near the tumour in severe combined immunodeficient beige mice and magnetically guided, up to 55% of MC-1 cells penetrated into hypoxic regions of HCT116 colorectal xenografts. Approximately 70 drug-loaded nanoliposomes were attached to each MC-1 cell. Our results suggest that harnessing swarms of microorganisms exhibiting magneto-aerotactic behaviour can significantly improve the therapeutic index of various nanocarriers in tumour hypoxic regions.

At a glance

Figures

left
  1. Assessment of the specificity of the MC-1 antibody in HCT116 colorectal xenografts in SCID beige mice.
    Figure 1
  2. MC-1 cells are preferentially located in the hypoxic regions of the xenografts.
    Figure 2
  3. Penetration of live MC-1 cells with and without magnetic field exposure in HCT116 xenografts following a peritumoral injection.
    Figure 3
  4. Superior penetration of MC-1 cells over passive diffusion in HCT116 xenografts demonstrated by two methods.
    Figure 4
  5. Targeting ratios of MC-1–LP in HCT116 xenografts.
    Figure 5
right




Oil companies continue to dominate the world.

Native Americans Are Barred From Disrupting Oil Pipeline Construction

A North Dakota federal court ordered Native American protesters Wednesday to stop blocking the construction of a $3.8 billion oil pipeline set to cross four states and major rivers, a Sioux official said.
The restraining order comes as construction at the site has beensuspended following days of protests.
“The tribe is committed to doing all it can to make sure the demonstrations … are done in the right way,” said Dave Archambault II, chairman of the Standing Rock Sioux Tribe, in a call with reporters Wednesday. “As we have said from the beginning, demonstrations regarding Dakota Access must be peaceful.”
On Monday, workers were instructed to leave their equipment after protesters walked onto the work site and surrounded machinery, the Bismarck Tribunereported. That same day the pipeline developer, Dakota Access, filed a lawsuit against the Standing Rock Sioux reservation alleging worker and law enforcement safety was at risk.
The so-called Bakken pipeline, a line about as long as the proposed Keystone XL, is set to cut through the Dakotas, Iowa, and Illinois diagonally. Owned by a subsidiary of Texas-based Energy Transfer Partners, every day the line will transport up to 570,000 barrels of sweet crude oil fracked from North Dakota’s oil-rich Bakken Formation, to a market hub near Patoka, Illinois.
Most of the affected land is private farmland, but the project does run through wildlife areas and sacred Native American sites, as well as major drinking water sources like the Mississippi, and the Missouri, the longest river in North America. Federal agencies have said the Bakken pipeline avoids “critical habitat,” and developers have assured states the pipeline is safe. Critics, on the other hand, consider the Bakken pipeline an unreasonable threat and say the line is poised to leak.
Iowa was the last state to bless the pipeline earlier this year after much opposition from environmentalists, Native Americans, and some farmers who ended up suing state regulators. Then last month, the U.S. Army Corps of Engineers established paths to avoid sacred sites and approved the last set of permits developers needed to build. The Standing Rock Sioux Tribe countered with a lawsuit against the agency to challenge the permits. A hearing is set for next week.
“The pipeline presents a threat to our land, our sacred sites, our water and to the people,” said Archambault, who has reached out to the White House and North Dakota senators. “Our basic message is that the Corps of Engineers has failed to follow the law and has failed to consider the impacts of the pipeline on Standing Rock Sioux Tribe.”
Archambault was among several protesters charged late last week with disorderly conduct or trespassing at a construction site located near where the Cannonball and Missouri rivers meet, according to published reports. Law officials first started detaining people Thursday, some two days after the protest began.
As the weekend progressed, the protest grew in size and attention with celebrities like actresses Shailene Woodley, Rosario Dawson, and Riley Keough voicing their opposition. In fact, Woodley, 24, was in the protest last week , the Bismarck Tribune reported.
“It is our responsibility to learn the narrative in which Native Americans recall their own history and are walking their own history, and this is a beautiful opportunity for that,” said Woodley, according Look to the Stars, a celebrity news site. “Not only are we saying enough is enough to the fossil-fuel industry but we’re saying enough is enough to silence. That’s why this fight is so profound to me.”
Though a restraining order is in place, the protest is likely to continue further away from the site.
The Bakken pipeline is scheduled to be operational by the end of the year.

Thursday, August 11, 2016

Pierre Markuse has let the Cat out of the bag!

Hello Gentle People:

 SHHH....keep it a secret! Don't let anybody know how bad the heat is getting! Pretend everything is fine in your air conditioned home or apartment or car. Keep your car motor running and don't worry about global warming. After all, you just bought your new shiny internal combustion engine at zero percent financing and global warming or no global warming, you are not going to give up your cool ride for anybody!

 Who cares if the Glaciers have melted! Who cares if the Arctic has melted! Who cares if old people die in the heat and desertification replaces farm lands! Monsanto will continue to feed you with great tasting genetically modified and pesticide resistant Serial crops grown in other countries and McDonalds can provide you with nice fat and juicy hormone fed beef. And don't worry about those pesky environment protection people. They have limited power and the super rich Oil producing countries will do their best to dominate the governments of the world so that nothing changes to disturb your comfortable life styles.

  In some areas of the world the opposite is true. Flooding and hurricanes and humidity are the norm and native Trees are dying by the thousands to be replaced by tropical species and insects that normally live in jungles. But hey! As long as you are comfortable in your air conditioned offices and homes and cars, the occasional Black Widow spider will not worry you! That's what pesticides are for! Why worry about the millions of suffering people who don't have the luxuries of an oil based industrial economy to keep them comfortable and so keep up the great secret and SHHHH!



NASA Analysis Finds July 2016 is Warmest on Record

July 2016 was the warmest July in 136 years of modern record-keeping, according to a monthly analysis of global temperatures by scientists at NASA’s Goddard Institute for Space Studies (GISS) in New York. Because the seasonal temperature cycle peaks in July, it means July 2016 also was warmer than any other month on record. July 2016’s temperature was a statistically small 0.1 degrees Celsius warmer than previous warm Julys in 2015, 2011 and 2009.

Full story here:
http://data.giss.nasa.gov/gistemp/news/20160816/

More information here:
http://www.giss.nasa.gov/

Where to start when looking for information on climate change?

Check out NASA's Global Climate Change Vital Signs of the Planet website with lots of information on global climate change:
http://climate.nasa.gov/

Image credit: NASA Goddard Institute for Space Studies

#science #earth  #climate   #climatechange   #globalwarming   #temperatureanomaly   #nasa   #giss  

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