Nelson Joseph Raglione <human4usbillions@gmail.com>	9:23 AM (5 hours ago)
to me

https://youtube.com/shorts/lLXC2j0vE1M?feature=share

Gentle People:

I highly recommend watching this short video. It is good common sense 

with a few exceptions. For example, If somebody advises 

me not to walk on a train track because it is dangerous 

and a train is coming, I would be wise to take his or her advice.

Apart from such exceptions, Sadhguru is right on target.  

N.J.R.

HAVE THEY SUCCEEDED IN 2023?

Complex Three-Dimensional Kidney Tissue Created in the Lab From Scratch 

TOPICS:BiotechnologyKidneyOrgan TransplantStem CellsTissue

By KUMAMOTO UNIVERSITY FEBRUARY 1, 2022

Researchers in Japan have generated a kidney-like 3D tissue, consisting of extensively branched tubules, from cultured mouse embryonic stem cells. Credit: Dr. Shunsuke Tanigawa

A research team based in Kumamoto University (Japan) has created complex 3D kidney tissue in the lab solely from cultured mouse embryonic stem (ES) cells. These organoids could lead the way to better kidney research and, eventually, artificial kidneys for human transplant.

By focusing on an often-overlooked tissue type of organoid generation research, a type of organ tissue made up of various support and connective tissues called the stroma, Dr. Ryuichi Nishinakamura and his team were able to generate the last of a three-part puzzle that they had been working on for several years. Once the three pieces were combined, the resulting structure was found to be kidney-like in its architecture. The researchers believe that their work will be used to advance kidney research and even lead to a transplantable organ in the future.

Researchers in Japan have generated a kidney-like 3D tissue, consisting of many types of kidney-specific structures, from cultured mouse embryonic stem cells. Credit: Dr. Shunsuke Tanigawa

The kidney is a very important organ for continued good health because it acts as a filter to extract waste and excess water from blood. It is a complex organ that develops from the combination of three components. Protocols have already been established by various research teams, including Dr. Nishinakamura’s team at the Institute of Molecular Embryology and Genetics (IMEG) at Kumamoto University, to induce two of the components (the nephron progenitor and the ureteric bud) from mouse ES cells.

In this, their most recent work, the IMEG team has developed a method to induce the third and final component, kidney-specific stromal progenitor, in mice. Furthermore, by combining these three components in vitro, the researchers were able to generate a kidney-like 3D tissue, consisting of extensively branched tubules and several other kidney-specific structures.

The researchers believe that this is the first ever report on the in-lab generation of such a complex kidney structure from scratch. The IMEG team has already succeeded in inducing the first two components from human iPS cells. If this last component can also be generated from human cells, a similarly complex human kidney should be achievable.

“We are now working very hard to generate a fully functional human kidney,” said Dr. Nishinakamura. “We hope to use our developments to screen drugs for various diseases, and for transplantation in the long run.”

Reference: “Generation of the organotypic kidney structure by integrating pluripotent stem cell-derived renal stroma” by Shunsuke Tanigawa, Etsuko Tanaka, Koichiro Miike, Tomoko Ohmori, Daisuke Inoue, Chen-Leng Cai, Atsuhiro Taguchi, Akio Kobayashi and Ryuichi Nishinakamura, 1 February 2022, Nature Communications.
DOI: 10.1038/s41467-022-28226-7

Smart Life Reports

CONGRATULATIONS ON "COMPLEX THREE-DIMENSIONAL KIDNEY TISSUE CREATED IN THE LAB! GREAT WORK!     N.J. raglione. journalist. 

"The secret to a happy life -- lessons from 8 decades 

of research

The happiest and healthiest people are those who have warm connections with others, says psychiatrist 

Robert Waldinger, who leads the Harvard Study of Adult Development -- one of the longest-running studies 

of adult life ever conducted. Exploring the crucial link between social bonds and quality of life, he shares 

wisdom and insights into how to identify and strengthen the relationships that impact your well-being most. 

When it comes to the people in your inner circle, "Turn toward the voices that make you feel more open

 and more inclusive," he says. (This conversation, hosted by TED current affairs curator Whitney Pennington

 Rodgers, was part of an exclusive TED Membership event. 

Visit ted.com/membership to become a TED Member.)

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Well, one of the best theories, for which there's now some pretty good evidence, is based on the idea of stress. That, as we know, stress is an inevitable part of all of our lives. Stress happens to us every day. And what we find is that good relationships turn out to be stress regulators. So let me give you an example. Let's say that I have something upsetting happen to me during the day,and I find myself, like, ruminating about it and really thinking about it and unhappy. I can feel my body go into what we call fight or flight response where literally my heart rate goes up and I might start sweating a little bit and I'm just not feeling as well. Now, what we're meant to do is to come back to equilibriumwhen a stressor goes away. That's the way the body is supposed to work. But what happens if I go home at the end of my upsetting day and I have somebody to talk to? Either I can call someone on the phone or it's somebody I live with. I can literally feel my body calm down. I can feel that fight or flight response subside.

But what if I don't have anybody to go home to? What if there's nobody I can call? What we find is that people who are isolated, are lonely, don't have those stress regulators that we get from good relationships and that we stay in chronic fight or flight mode, that our bodies have this chronic stress, chronic levels of inflammation and circulating stress hormones that wear away our happiness and break down different body systems.

Well, what kinds of relationships seem essential to well-being?And this is interesting. We asked people who were our original participants in our study. We asked them, Who could you call in the middle of the night if you were sick or scared? And many of our people could list several other people they could call if they were in trouble. Some people couldn't list anyone. There wasn't a person on the planet who they could turn to if they were sick or scared. And what we find is that having at least one person in your life who you feel really has your back, who you could go to if you were in trouble, that's essential for maintaining our happiness and our health. When we asked these same people, when they got to be in their 80s, to look back on their lives and to tell us what they were proudest of, almost everybody said something about their relationships. They didn't say, "I made a lot of money"or "I won some big awards." They said, "I was a good mentor," "I was a good friend," "I raised healthy kids," "I was a good partner."And so what we find is that what seems to mean the most to people when they get to the end of their lives is the strength and the warmth of their connections to others."