ATTENTION WORLD SCIENTISTS!
Can rapid viral mutations be used to the benefit of today's researchers in the development of attenuated vaccines. How quickly does the SARS-CoV-2 virus mutate? "By serial passage of a virus through a different species, the virus becomes more adapted to that species, and less adapted to its original host, deceasing virulence with respect to the original host (e.g. it is "attenuated"). ..
Having discovered how to vaccinate against microorganisms, Rabies presented a new obstacle for Louis Pasteur in the development of a successful vaccine. Unlike chicken cholera and anthrax, both caused by bacterium, the microorganism causing the Rabies disease could not be specifically identified, meaning Pasteur would not be able to develop the vaccine in vitro (in the laboratory).
Pasteur did not know this at the time, but the reason he could not find the microorganism is because rabies is a viral disease. Viruses are small infectious agents that replicate quickly and have a high mutation rate. These rapid mutations can be used to the benefit of researchers in the development of an attenuated vaccine. By serial passage of a virus through a different species, the virus becomes more adapted to that species, and less adapted to its original host, deceasing virulence with respect to the original host (e.g. it is “attenuated”). By passing the virus through rabbits, Pasteur made the virus less dangerous to human hosts, while still giving the body enough information to recognize the antigen and develop immunity to the “wild” version of the disease.
Louis Pasteur in his laboratory, painting by Albert Edelfeldt in 1885.
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Attention world scientists,,,can the same process of passing a SARS-COV-2 through a rabbit and allowing the virus to mutate and adapt to rabbit cells, reduce the virulence of the virus and thus make the weakened virus usable as a vaccine in humans?
If you are using a similar method in vitro, and it works,..great! But if not Louis Pasteur may have left important information for you!
Personally, I like what Leor Weinberger discovered in the back of his laboratory.
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