Thursday, August 3, 2017

OUR INTERNATIONAL INDEX OF BEST WEB SITES.  IF SOME LINKS DON'T WORK TRY COPYING 

 DIRECTLY INTO GOOGLE. THIS holiday season visit site number 5 for great

 black and white fun movies.

2. =  HTTP://WWW.NETFLIX.COM/WI       

3.=   http://www.webcrawler.com </> 

4.=   https://www.google.ca/?gws_rd=cr&ei=mKPmUor8O4zxrAGy44BY </>

24.=  https://plus.google.com/u/0/                           
25.=   https://www.nasa.gov/image-feature/goddard/coronal-hole-front-and-center                        
30.=  http://www.iTooch.com </> 31. = http://www.Netmaths.com </> 32. = http://www.Evernote.com</>
33. = http://www.abmaths.com</> 34. = http://www.Sciences.com</> 35. =
36. = http://www.human4us2.blogspot.ca      37. = https://plus.google.com/u/0/ </>
38.=  http://www.jaccorde.com</>
39.=  http://www.Atlasdumonde.com </> 40.= http://www.Echecs.com </>
46.=  https://www.reneesgarden.com/blogs/gardening-resources/tagged/container-gardening                                       
49.=  http://eol.org/ </>
55.=  https://en.wikipedia.org/wiki/Street_lighthttps://en.wikipedia.org/wiki/Street_light
62.= http://hyperphysics.phy-astr.gsu.edu/hbase/hframe.html      (For the super intelligent.)
64.= https://www.youtube.com/watch?v=iFDe5kUUyT0   (The secret of money.)
65 = https://www.youtube.com/watch?v=kMANwvYtx8sh  (Subtle influences on the human brain.)

Let's demand technology that serves us, not advertising.

 
74,466
people want to change the industry

Technology is hijacking our minds.

Advertising-fueled technology companies are trapped in a race to get our attention.
We as individuals can try to use our devices more responsibly, but it's our willpower against hundreds of engineers who are paid to keep us glued to the screen:
  • YouTube autoplays more videos to keep us from leaving.
  • Instagram shows new likes one at a time, to keep us checking for more.
  • Facebook wants to show whatever keeps us scrolling.
  • Snapchat turns conversations into streaks we don't want to lose.
  • Our media turns events into breaking news to keep us watching.
These are not neutral tools.
They are part of a system designed to keep us hooked.

But it's changing the fabric of society.
It's changing political discourse.
It's changing our children.
The answer isn't to abandon technology. 
The answer is to change the technology industry to put our best interests first.

60 Minutes: "Brain Hacking" with former Google design ethicist Tristan Harris.
60 Minutes: "Brain Hacking" with former Google design ethicist Tristan Harris.

We need your help.

Time Well Spent is a movement to stop technology platforms from hijacking our minds, and to start putting our best interests first.

 

Plastic straws are a nightmare for Turtles.

McDonald's: End the Use of Plastic Straws
 
Sign Now
 
Joseph,
A viral video showing a team of researchers attempting to remove an obstruction from the nose of a sea turtle painful to watch. At the end of the struggle, once the blockage is ripped free, it's revealed to be a plastic straw.
Plastic straws are a nightmare for the environment and our wildlife.
These single-use conveniences are trashing the planet. There's not a beach around the globe that is free of this pollution. Our creeks, rivers, lakes and oceans are all littered with plastic straws. Wildlife, such as the sea turtle, can confuse straws for food and cause themselves great harm.
A post-mortem just completed on a Cuvier’s beaked whale that was found dead on a Scottish beach determined the animal was killed by plastic pollution.
The petroleum-based, polypropelene straw is an environmental nightmare, and it's time we WAKE UP. In the United States alone, people use more than 500 million straws EVERY DAY. Stretched end to end, they could circle the globe 2 & 1/2 times.
McDonald's, with its 35,000 worldwide locations, is an enormous source for these plastic disasters. McDonald's has been a leader in reducing waste, and transitioning its paper and cardboard to more sustainable sources. It's time they turn their attention to their plastic problem.
If enough of us take action together, we can show McDonald's that this is an issue they should address immediately.
Thank you for standing with wildlife,
 Aaron V.
The Care2 Petitions Team
 

Stabilizing the Peptide protein may prevent Alzeimers.

Never before seen images of early stage Alzheimer’s disease
Researchers at Lund University in Sweden have used the MAX IV synchrotron in Lund – the strongest of its kind in the world - to produce images that predate the formation of toxic clumps of beta-amyloid, the protein believed to be at the root of Alzheimer’s disease. The unique images appear to contradict a previously unchallenged consensus. Instead of attempting to eliminate beta-amyloid, or so-called plaques, the researchers now suggest stabilizing the protein.

It is a long-held belief in the scientific community that the beta-amyloid plaques appear almost instantaneously. Hence the term “popcorn plaques”. The infrared spectroscopy images, however, revealed something entirely different.

The researchers could now see structural, molecular changes in the brain.

“No one has used this method to look at Alzheimer’s development before. The images tell us that the progression is slower than we thought and that there are steps in the development of Alzheimer’s disease that we know little about. This, of course, sparked our curiosity,” says Gunnar Gouras, professor in experimental neurology at Lund University and senior author of the study.

What was happening at this previously unknown phase? Through biochemical identification the first author of the study, Oxana Klementieva, was able to look closer at these early brain changes.

The results revealed another discovery. Namely, that the beta-amyloid did not appear as a single peptide, a widely held belief in the field, but as a unit of four peptides sticking together, a tetramer.

This breakthrough offers a new hypothesis to the cause of the disease. The abnormal separation of these four peptides could be the start of the beta-amyloid aggregation that later turns into plaques.

Source & further reading
http://www.lunduniversity.lu.se/article/never-before-seen-images-of-early-stage-alzheimers-disease

Journal article:
http://www.nature.com/articles/ncomms14726

Illustration: Per Uvdal

#neuroscience #alzheimersdisease #betaamyloid #amyloidplaques #research #medicine
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Wednesday, August 2, 2017

Promising new Gene editing may alter birth defects.

AUGUST 2, 2017 / 1:01 PM / 11 HOURS AGO

U.S. scientists able to alter genes of human embryos

4 MIN READ
Juan Carlos Izpisua Belmonte, Professor at Salk Institute's Gene Expression Laboratory and Jun Wu, Salk staff Scientist are pictured in this handout photo obtained by Reuters, August 2, 2017. Salk Institute/Handout via REUTERS
U.S. scientists have succeeded in altering the genes of a human embryo to correct a disease-causing mutation, making it possible to prevent the defect from being passed on to future generations.
The milestone, reported in a paper released online August 2 in Nature, was confirmed last week by Oregon Health and Science University (OHSU), which collaborated with the Salk Institute and Korea's Institute for Basic Science to use a technique known as CRISPR-Cas9 to correct a genetic mutation for hypertrophic cardiomyopathy.
Until now, published studies using the technique had been done in China with mixed results.
CRISPR-Cas9 works as a type of molecular scissors that can selectively trim away unwanted parts of the genome, and replace it with new stretches of DNA.
"We have demonstrated the possibility to correct mutations in a human embryo in a safe way and with a certain degree of efficiency," said Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory and a co-author of the study.
To increase the success rate, his team introduced the genome editing components along with sperm from a male with the targeted gene defect during the in vitro fertilization process. They found that the embryo used the available healthy copy of the gene to repair the mutated part.
The Salk/OHSU team also found that its gene correction did not cause any detectable mutations in other parts of the genome - a major concern for gene editing.
Still, the technology was not 100 percent successful. It increased the number of repaired embryos from 50%, which would have occurred naturally, to 74%.
The embryos, tested in the laboratory, were allowed to develop for only a few days.
"There is still much to be done to establish the safety of the methods, therefore they should not be adopted clinically," Robin Lovell-Badge, a professor at London's Francis Crick Institute who was not involved in the study, said in a statement.

'Utmost Caution'

Washington's National Academy of Sciences (NAS) earlier this year softened its previous opposition to the use of gene editing technology in human embryos, which has raised concerns it could be used to create so-called designer babies. There is also a fear of introducing unintended mutations into germline cells.
"No one is thinking about this because it is practically impossible at this point," Izpisua Belmonte said. "This is still very basic research ... let alone something as complex as what nature has done for millions and millions of years of evolution."
An international group of 11 organizations, including the American Society of Human Genetics and Britain's Wellcome Trust, on Wednesday issued a policy statement recommending against genome editing that culminates in human implantation and pregnancy, while supporting publicly funded research into its potential clinical applications.
Salk's Izpisua Belmonte, emphasizing that much more study is needed, said the most important practical application for the new technology could be in correcting genetic mutations in babies either in utero or right after they are born.
"It is crucial that we continue to proceed with the utmost caution, paying the highest attention to ethical considerations," he said.
Nature 2017.
This story was refiled Refiling with source link at end of story and modifications throughout for professional readers

  Hello my good friend Valdemar Oliveira! I am happy to hear you had a successfull heart operation.  I hope you live to be 110. I may not be...