Tuesday, February 20, 2018

Find flow and be happy!.


The One Word That Sums Up Everything You Need To Do To Be Happier

Be-Happier
That word is “PERMA.” It’s an acronym for:
  • Positive Emotion
  • Engagement
  • Good Relationships
  • Meaning
  • Accomplishment
Martin Seligman is a professor at the University of Pennsylvania and one of the foremost experts on the study of happiness. He gave the following talk in 2011 explaining “PERMA”, the research behind it, and how we can use it to improve our lives. I (Eric Barker) will break it down after the video.

For the longest time the model of happiness we’ve had has followed how we look at health: If you’re sick, we try to make you not-sick. If you’re depressed, we try to make you not-depressed.
But can’t we do more than merely eliminating suffering? Can’t we try to go from normal to happier? Can we flourish?
Seligman explains that the things we need to do to be happier are all tied up in PERMA. So let’s break down what Seligman has to say.

P: Positive Emotion

We need 3 positive things for every negative thing in order to thrive.
Psychologist Barbara Frederickson is an expert on flourishing and has been an advocate of finding ways to bring more positive emotions into our lives. In her research she discovered a critical 3 to 1 ratio, indicating that we need to have three positive emotions for every negative one in order to thrive.
And:
Frederickson has found out that if we really want to prosper, we shouldn’t try to eliminate negative emotions, rather, we should work on keeping the ratio at three positive for every one negative. Most of us, she has found, have two positive experiences for every negative. This gets us by, but it is effectively languishing.
This also ties in to what Seligman explains is one of the most powerful happiness boosting exercises: 3 blessings.
This technique has been proven again and again. Seligman explains it in his book Flourish: A Visionary New Understanding of Happiness and Well-being:
Every night for the next week, set aside ten minutes before you go to sleep. Write down three things that went well today and why they went well. You may use a journal or your computer to write about the events, but it is important that you have a physical record of what you wrote. The three things need not be earthshaking in importance (“ My husband picked up my favorite ice cream for dessert on the way home from work today”), but they can be important (“ My sister just gave birth to a healthy baby boy”).
Next to each positive event, answer the question “Why did this happen?”

E: Engagement

This is what is often called flow. It’s when you’re so wrapped up in what you’re doing that the world fades away:
Flow is the mental state of operation in which a person performing an activity is fully immersed in a feeling of energized focus, full involvement, and enjoyment in the process of the activity… The hallmark of flow is a feeling of spontaneous joy, even rapture, while performing a task although flow is also described… as a deep focus on nothing but the activity – not even oneself or one’s emotions.
When do you usually feel flow? It’s when you’re challenged but not beyond your skill level. Passive activities don’t create flow. Neither do overwhelming challenges.
There are a handful of things that need to be present for you to experience flow:
  • Clear goals that, while challenging, are still attainable.
  • Immediate feedback.
  • Knowing that the task is doable; a balance between personal skill level and the challenge presented.
  • Strong concentration and focused attention.
  • The activity is intrinsically rewarding.
More on creating flow here.

R: Relationships

Seligman talks about a relatively recent discovery in what makes good relationships. Often it’s not how you fight, it’s how you celebrate:
Shelly Gable, professor of psychology at the University of California at Santa Barbara, has demonstrated that how you celebrate is more predictive of strong relations than how you fight.
He also covers the type of speaking that improves relationships. It’s called “active-constructive.”

M: Meaning

Meaning comes from belonging to and serving something that is bigger than you are.
Can we build meaning in our lives? Yes. Seligman explains one exercise is to write your own obituary. What do you want your legacy to be?
Via Richard Wiseman’s excellent book 59 Seconds: Change Your Life in Under a Minute:
Asking people to spend just a minute imagining a close friend standing up at their funeral and reflecting on their personal and professional legacy helps them to identify their long-term goals and assess the degree to which they are progressing toward making those goals a reality.
In the past I’ve encouraged my students to draft their obituary as part of an extra-credit exercise, asking them to write it as they wished it to appear after a long life. I know it sounds morbid, but this assignment is an excellent way to expose the gap between how people live their lives and how they want to be remembered. It’s a sobering experience at any age. The real benefit, of course, is that the writer gets to confront any such inconsistencies before it’s too late. I can’t tell you how many students have told me that this experience was a real wake-up call for them— one that I hope has changed many lives. We all must ask ourselves, if our obituaries were written today, would we be happy with what was written?
9 minutes in to his famous Stanford commencement speech Steve Jobs discusses the importance he placed on thinking about death during life:
“Remembering that I’ll be dead soon is the most important tool I’ve ever encountered to help me make the big choices in life.”

A: Achievement

What has research shown is most tied to success? Seligman says it’s “grit“. Perseverance.
Via Dan Pink’s excellent book Drive: The Surprising Truth About What Motivates Us.
The best predictor of success, the researchers found, was the prospective cadets’ ratings on a noncognitive, nonphysical trait known as “grit”—defined as “perseverance and passion for long-term goals.”
More about grit (and how to be “grittier”) here.
Want to learn more about how to use these ideas to be happier? Check out this post.
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Sunday, February 18, 2018

Longevity now!

We Read This 800-Page Report on the State of Longevity Research So You Don’t Have To

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The longevity field is bustling but still fragmented, and the “silver tsunami” is coming.
That is the takeaway of The Science of Longevity, the behemoth first volume of a four-part series offering a bird’s-eye view of the longevity industry in 2017. The report, a joint production of the Biogerontology Research FoundationDeep Knowledge Life Science, Aging Analytics Agency, and Longevity.International, synthesizes the growing array of academic and industry ventures related to aging, healthspan, and everything in between.
This is huge, not only in scale but also in ambition. The report, totally worth a read here, will be followed by four additional volumes in 2018, covering topics ranging from the business side of longevity ventures to financial systems to potential tensions between life extension and religion.
And that’s just the first step. The team hopes to publish updated versions of the report annually, giving scientists, investors, and regulatory agencies an easy way to keep their finger on the longevity pulse.
“In 2018, ‘aging’ remains an unnamed adversary in an undeclared war. For all intents and purposes it is mere abstraction in the eyes of regulatory authorities worldwide,” the authors write.
That needs to change.
People often arrive at the field of aging from disparate areas with wildly diverse opinions and strengths. The report compiles these individual efforts at cracking aging into a systematic resource—a “periodic table” for longevity that clearly lays out emerging trends and promising interventions.
The ultimate goal? A global framework serving as a road map to guide the burgeoning industry. With such a framework in hand, academics and industry alike are finally poised to petition the kind of large-scale investments and regulatory changes needed to tackle aging with a unified front.
global-longevity-science-landscape-2017-geroscience-companies
Infographic depicting many of the key research hubs and non-profits within the field of geroscience.
Image Credit: Longevity.International

The Aging Globe

The global population is rapidly aging. And our medical and social systems aren’t ready to handle this oncoming “silver tsunami.”
Take the medical field. Many age-related diseases such as Alzheimer’s lack effective treatment options. Others, including high blood pressure, stroke, lung or heart problems, require continuous medication and monitoring, placing enormous strain on medical resources.
What’s more, because disease risk rises exponentially with age, medical care for the elderly becomes a game of whack-a-mole: curing any individual disease such as cancer only increases healthy lifespan by two to three years before another one hits.
That’s why in recent years there’s been increasing support for turning the focus to the root of the problem: aging. Rather than tackling individual diseases, geroscience aims to add healthy years to our lifespan—extending “healthspan,” so to speak.
Despite this relative consensus, the field still faces a roadblock. The US FDA does not yet recognize aging as a bona fide disease. Without such a designation, scientists are banned from testing potential interventions for aging in clinical trials (that said, many have used alternate measures such as age-related biomarkers or Alzheimer’s symptoms as a proxy).
Luckily, the FDA’s stance is set to change. The promising anti-aging drug metformin, for example, is already in clinical trials, examining its effect on a variety of age-related symptoms and diseases. This report, and others to follow, may help push progress along.
“It is critical for investors, policymakers, scientists, NGOs, and influential entities to prioritize the amelioration of the geriatric world scenario and recognize aging as a critical matter of global economic security,” the authors say.

Biomedical Gerontology

The causes of aging are complex, stubborn, and not all clear.
But the report lays out two main streams of intervention with already promising results.
The first is to understand the root causes of aging and stop them before damage accumulates. It’s like meddling with cogs and other inner workings of a clock to slow it down, the authors say.
The report lays out several treatments to keep an eye on.
Geroprotective drugs is a big one. Often repurposed from drugs already on the market, these traditional small molecule drugs target a wide variety of metabolic pathways that play a role in aging. Think anti-oxidants, anti-inflammatory, and drugs that mimic caloric restriction, a proven way to extend healthspan in animal models.
More exciting are the emerging technologies. One is nanotechnology. Nanoparticles of carbon, “bucky-balls,” for example, have already been shown to fight viral infections and dangerous ion particles, as well as stimulate the immune system and extend lifespan in mice (though others question the validity of the results).
Blood is another promising, if surprising, fountain of youth: recent studies found that molecules in the blood of the young rejuvenate the heartbrain, and muscles of aged rodents, though many of these findings have yet to be replicated.

Rejuvenation Biotechnology

The second approach is repair and maintenance.
Rather than meddling with inner clockwork, here we force back the hands of a clock to set it back. The main example? Stem cell therapy.
This type of approach would especially benefit the brain, which harbors small, scattered numbers of stem cells that deplete with age. For neurodegenerative diseases like Alzheimer’s, in which neurons progressively die off, stem cell therapy could in theory replace those lost cells and mend those broken circuits.
Once a blue-sky idea, the discovery of induced pluripotent stem cells (iPSCs), where scientists can turn skin and other mature cells back into a stem-like state, hugely propelled the field into near reality. But to date, stem cells haven’t been widely adopted in clinics.
It’s “a toolkit of highly innovative, highly invasive technologies with clinical trials still a great many years off,” the authors say.
But there is a silver lining. The boom in 3D tissue printing offers an alternative approach to stem cells in replacing aging organs. Recent investment from theMethuselah Foundation and other institutions suggests interest remains high despite still being a ways from mainstream use.

A Disruptive Future

“We are finally beginning to see an industry emerge from mankind’s attempts to make sense of the biological chaos,” the authors conclude.
Looking through the trends, they identified several technologies rapidly gaining steam.
One is artificial intelligence, which is already used tobolster drug discovery. Machine learning may also help identify new longevity genes or bring personalized medicine to the clinic based on a patient’s records or biomarkers.
Another is senolytics, a class of drugs that kill off“zombie cells.” Over 10 prospective candidates are already in the pipeline, with some expected to enter the market in less than a decade, the authors say.
Finally, there’s the big gun—gene therapy. The treatment, unlike others mentioned, can directly target the root of any pathology. With a snip (or a swap), genetic tools can turn off damaging genes or switch on ones that promote a youthful profile. It is the most preventative technology at our disposal.
There have already been some success stories in animal models. Using gene therapy, rodents given a boost in telomerase activity, which lengthens the protective caps of DNA strands, live healthier for longer.
“Although it is the prospect farthest from widespread implementation, it may ultimately prove the most influential,” the authors say.
Ultimately, can we stop the silver tsunami before it strikes?
Perhaps not, the authors say. But we do have defenses: the technologies outlined in the report, though still immature, could one day stop the oncoming tidal wave in its tracks.
Now we just have to bring them out of the lab and into the real world. To push the transition along, the team launched Longevity.International, an online meeting ground that unites various stakeholders in the industry.
By providing scientists, entrepreneurs, investors, and policy-makers a platform for learning and discussion, the authors say, we may finally generate enough drive to implement our defenses against aging. The war has begun.
Read the report in full here, and watch out for others coming soon here. The second part of the report profiles 650 (!!!) longevity-focused research hubs, non-profits, scientists, conferences, and literature. It’s an enormously helpful resource—totally worth keeping it in your back pocket for future reference.
Image Credit: Worraket / Shutterstock.com
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Shelly Xuelai Fan is a neuroscientist at the University of California, San Francisco, where she studies ways to make old brains young again. In addition to research, she's also an avid science writer with an insatiable obsession with biotech, AI and all things neuro. She spends her spare time kayaking, bike camping and getting lost in the woods.

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Wednesday, February 14, 2018

Canada's Tax Loopholes.

Wednesday, February 7, 2018

Great thoughts from Peter Diamandis.

Here Are 4 Significant Things We Can Do to Combat Climate Change Now

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Earlier this month, 13 US government agencies (NOAA, NASA, DOE, etc.) concluded that climate change is real and caused mainly by human activity.
There is no question that this is happening…
The only question now is: what do we do about it?
This post looks at four options:
  1. Pass government legislation that incentivizes carbon abatement.
  2. Drive mass adoption of solar energy and battery technology.
  3. Adapt ourselves and our civilization to the changing climate.
  4. Invest in geo-scale engineering projects.
Let’s dive in.

1. Government Regulation and Top-Down Incentives

We’ve seen many government debates, laws passed, and treaties signed. We’ve heard a lot about the efficacy of cap and trade, taxing carbon, and other regulations that incentivize carbon abatement.
While we should rally behind policies that can assist in slowing the rise of global temperatures, forgive me if I don’t depend on this option to handle the problem.
Many special interests and scientifically ignorant members of the electorate make this option unlikely and risky to baseline as our primary strategy.
The time for radical action is now.

2. Make Renewables So Cheap They Kill Fossil Fuels

Society faced a similar environmental crisis 120 years ago…
At the end of the 19th century, London was becoming uninhabitable because of the accumulation of horse manure.
As citizens moved from the rural countryside to the urban cities, they brought with them their motive force, the horse, and the piles of horse manure piled up rapidly, bringing disease. People were absolutely panicked. Because of their anchoring bias, they couldn’t imagine any other possible solutions. No one had any idea that a disruptive technology—the automobile—was coming.
What is today’s equivalent transformative technology? Clearly, it’s the mass adoption of renewable energy: solar, wind, geothermal and nuclear.
Let’s look at solar alone. Few people have any idea that 8,000 times more energy from the sun hits the surface of the earth in a day than we consume as a human race.
All the energy we could ever need is literally raining down from above. A squanderable abundance of energy.
These staggering numbers in combination with an exponential decline in photovoltaic solar energy costs (dollar-per-watt price of solar cells) put us on track to meet between 50 percent and 100 percent of the world’s energy production from solar (and other renewables) in the next 20 years.
Even better, the poorest countries in the world are the sunniest.
At the same time that renewable energy sources are on the rise, the demise of the internal combustion car is synergistically bringing about the end of the era of fossil fuels.
India, France, Britain, and Norway plan to completely ditch gas and diesel cars in favor of cleaner electric vehicles in the coming decades. At least 10 other countries (including China and India) have set sales targets for electric cars.
In the last year alone, every manufacturer has announced aggressive plans for electric vehicles. Ford, for example, is investing $4.5 billion in electric cars, adding 13 electric cars and hybrids by 2020, making more than 40 percent of its lines electrified.
An EV market of two models in 2010 has climbed to more than 25 models today.
At the same time, many automotive companies (e.g., Volvo) have announced they’re phasing out their internal combustion cars altogether.
Batteries: It’s next reasonable to ask whether the required battery technology will advance fast enough to give us the storage capacity needed for an “all-electric economy.” However, battery performance pricing ($/kWh) is dropping faster than even the optimists projected.
The bottom line: Our second option for combating climate change is to make renewable energy so cheap, such a no-brainer, that fossil fuels disappear for the same reason the Stone Age vanished: Not for a lack of stones, but for a 10x better option.
Abundance-minded entrepreneurs have the option to make solar and renewables easier, cheaper, and better, putting the petroleum, natural gas, and coal industries out of business.

3. Adapting to a Warmer World

The Earth’s environment has been continuously changing for more than four billion years.
When life first emerged on Earth, our atmosphere was a deadly combination of carbon dioxide, ammonia, and methane. Then, about three billion years ago, a poisonous and corrosive gas called oxygen came about from a process called “photosynthesis,” a process that transformed the climate and killed many of the existing life forms.
Ultimately life, whether it is microbial or homo sapiens, changes the environment. Our challenge today is the speed with which humanity’s use of fossil fuels has destabilized our ecosystem.
So, the question is, in parallel with items 1, 2, and 4 in this post, do we accelerate our efforts to adapt to these changes as well?
One such example comes from China, where a team of scientists have successfully modified rice to grow in saltwater, which will allow them to feed their populace as sea levels rise. Cornell University projects that 2 billion people—around 20% of the world’s population—are at risk of being displaced by rising sea levels.

4. Geoscale Engineering: A Solution in Space

I recently had a conversation with a billionaire friend of mine from Silicon Valley who is committing his wealth and intellect to solving our climate problem. He’s tired of all the inaction and sees the climate crisis as one of humanity’s greatest existential threats today.
One solution that I discussed with him that I find compelling and elegant is called a “sunshade.”
Imagine a large, deployable mega-structure that sits between the earth and sun, and blocks out very small (<0.1 percent) (variable) fraction of the photons coming from the sun to the earth.
The preferred location for such a sunshade is near the Earth-Sun inner Lagrange point (L1) in an orbit with the same 1-year period as the Earth, and in-line with the sun at a distance ≥ 1,500,000 kilometers from Earth.
While researching the idea, I found three well documented write-ups:
  1. In 1989, James Early (from the Lawrence Livermore National Laboratory) proposed putting a giant, 2000 km-wide glass deflector at L1.
  2. A 1992 NASA report suggested lifting 55,000 “solar sails” into orbit at L1, each with an area of 100 km2, blocking about 1 percent of sunlight.
  3. In 2007, Roger Angel (an astronomer from the University of Arizona), suggested creating a “cloud” of tiny sunshades at L1, each weighing about 1.2 grams and measuring 60 centimeters in diameter.
All of these proposals have their respective limitations, whether it’s cost, technical feasibility, and so on.
Roger Angel’s solution, which proposed millions of micro-shades rather than one large, expensive structure, has various pros and cons. It’s estimated that his concept could be developed and deployed in 25 years at a cost of a few trillion dollars, <0.5 percent of the world’s GDP over that time.
This is just one example of many geoscale engineering projects worth exploring.
Others (which I don’t like as much, because they may not be as easily reversible and controllable) include documented ideas like seeding our oceans with iron to increase the growth of plankton, or deliberately injecting the stratosphere with sulphur compounds to increase the Earth’s reflectivity.
Clearly, I can’t put forth this option without acknowledging that we can’t fully know the secondary effects of these efforts. As Jim Haywood, professor of Atmospheric Science at University of Exeter said in an interview, “…there’s a healthy fear surrounding a technique that, without being hyperbolic, would aim to hack the planet’s climate and block out the sun.”

Final Thoughts

We can either wait for climate change to continue to decimate elements of our society, or we can begin focusing aggressively on solutions.
Given our access to exponential technologies, I am far more hopeful about our ability to address the climate crisis today, rather than 50, or even 20, years ago.
We can fix the problem—we just need to focus our intellect, resources, and technology, and focus it fast.
Over the next decade, as climate change becomes more devastating and visible, great thinkers and entrepreneurs will emerge with even more surprising solutions to help tackle this grand challenge.
As I have often said, the world’s biggest problems are the world’s biggest business opportunities.
Image Credit: Wang An Qi / Shutterstock.com
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Dr. Peter Diamandis is the Chairman and CEO of the X PRIZE Foundation, which leads the world in designing and launching large incentive prizes to drive radical breakthroughs for the benefit of humanity. Best known for the $10 million Ansari X PRIZE for private spaceflight, the Foundation is now launching prizes in Exploration, Life Sciences, Energy, and Education. Diamandis is also the co-Fou...

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