Thursday, October 12, 2017

From a genius kid...an exponential growth warning!

Does Our Survival Depend on Relentless Exponential Growth?

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Malthus had a fever dream in the 1790s. While the world was marveling in the first manifestations of modern science and technology and the industrial revolution that was just beginning, he was concerned. He saw the exponential growth in the human population as a terrible problem for the species—an existential threat. He was afraid the human population would overshoot the availability of resources, and then things would really hit the fan.
“Famine seems to be the last, the most dreadful resource of nature. The power of population is so superior to the power of the earth to produce subsistence for man, that premature death must in some shape or other visit the human race. The vices of mankind are active and able ministers of depopulation.”
So Malthus wrote in his famous text, an essay on the principles of population.
But Malthus was wrong. Not just in his proposed solution, which was to stop giving aid and food to the poor so that they wouldn’t explode in population. His prediction was also wrong: there was no great, overwhelming famine that caused the population to stay at the levels of the 1790s. Instead, the world population—with a few dips—has continued to grow exponentially ever since. And it’s still growing.
There have concurrently been developments in agriculture and medicine and, in the 20th century, the Green Revolution, in which Norman Borlaugensured that countries adopted high-yield varieties of crops—the first precursors to modern ideas of genetically engineering food to produce better crops and more growth. The world was able to produce an astonishing amount of food—enough, in the modern era, for ten billion people. It is only a grave injustice in the way that food is distributed that means 12 percent of the world goes hungry, and we still have starvation. But, aside from that, we were saved by the majesty of another kind of exponential growth; the population grew, but the ability to produce food grew faster.
In so much of the world around us today, there’s the same old story. Take exploitation of fossil fuels: here, there is another exponential race. The exponential growth of our ability to mine coal, extract natural gas, refine oil from ever more complex hydrocarbons: this is pitted against our growing appetite. The stock market is built on exponential growth; you cannot provide compound interest unless the economy grows by a certain percentage a year.

“This relentless and ruthless expectation—that technology will continue to improve in ways we can’t foresee—is not just baked into share prices, but into the very survival of our species.”

When the economy fails to grow exponentially, it’s considered a crisis: a financial catastrophe. This expectation penetrates down to individual investors. In the cryptocurrency markets—hardly immune from bubbles, the bull-and-bear cycle of economics—the traders’ saying is “Buy the hype, sell the news.” Before an announcement is made, the expectation of growth, of a boost—the psychological shift—is almost invariably worth more than whatever the major announcement turns out to be. The idea of growth is baked into the share price, to the extent that even good news can often cause the price to dip when it’s delivered.
In the same way, this relentless and ruthless expectation—that technology will continue to improve in ways we can’t foresee—is not just baked into share prices, but into the very survival of our species. A third of Earth’s soil has been acutely degraded due to agriculture; we are looming on the brink of a topsoil crisis. In less relentless times, we may have tried to solve the problem by letting the fields lie fallow for a few years. But that’s no longer an option: if we do so, people will starve. Instead, we look to a second Green Revolution—genetically modified crops, or hydroponics—to save us.
Climate change is considered by many to be an existential threat. The Intergovernmental Panel on Climate Change has already put their faith in the exponential growth of technology. Many of the scenarios where they can successfully imagine the human race dealing with the climate crisis involve the development and widespread deployment of carbon capture and storage technology. Our hope for the future already has built-in expectations of exponential growth in our technology in this field. Alongside this, to reduce carbon emissions to zero on the timescales we need to, we will surely require new technologies in renewable energy, energy efficiency, and electrification of the transport system.
Without exponential growth in technology continuing, then, we are doomed. Humanity finds itself on a treadmill that’s rapidly accelerating, with the risk of plunging into the abyss if we can’t keep up the pace. Yet this very acceleration could also pose an existential threat. As our global system becomes more interconnected and complex, chaos theory takes over: the economics of a town in Macedonia can influence a US presidential election; critical infrastructure can be brought down by cybercriminals.
New threats, such as biotechnology, nanotechnology, or a generalized artificial intelligence, could put incredible power—power over the entire species—into the hands of a small number of people. We are faced with a paradox: the continued existence of our system depends on the exponential growth of our capacities outpacing the exponential growth of our needs and desires. Yet this very growth will create threats that are unimaginably larger than any humans have faced before in history.

“It is necessary that we understand the consequences and prospects for exponential growth: that we understand the nature of the race that we’re in.”

Neo-Luddites may find satisfaction in rejecting the ill-effects of technology, but they will still live in a society where technology is the lifeblood that keeps the whole system pumping. Now, more than ever, it is necessary that we understand the consequences and prospects for exponential growth: that we understand the nature of the race that we’re in.
If we decide that limitless exponential growth on a finite planet is unsustainable, we need to plan for the transition to a new way of living before our ability to accelerate runs out. If we require new technologies or fields of study to enable this growth to continue, we must focus our efforts on these before anything else. If we want to survive the 21st century without major catastrophe, we don’t have a choice but to understand it. Almost by default, we’re all accelerationists now.
Image Credit: focal point / Shutterstock.com
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Monday, October 9, 2017

The Proterra Bus.1100 miles on single charge.

, partners with Van Hool for electric coaches

American electric bus maker Proterra made two important announcements today. The company unveiled its new dual motor all-electric drivetrain and it confirmed that it has been selected to make the electric powertrains for Van Hool’s first all-electric coach.
The bus maker confirmed that their recent 1,100 miles on a single charge record was achieved with the new system, which they introduced at the American Public Transit Association (APTA) Annual Meeting today:
“Designed for durability, Proterra’s DuoPower drivetrain features two electric motors that deliver an impressive 510 horsepower, accelerating a Catalyst bus from 0-20 mph in 4.5 seconds, while also achieving an industry-leading 26.1 MPGe. In addition, it can propel a bus up a 26 percent grade, which is more than twice the performance of the average 35- or 40-foot diesel bus, and 72 percent better than competing electric transit vehicles, making it an ideal option for transit agencies with steep hills.”
Here’s the impact of the new system on their 40-ft bus and in comparison to the competition:

Ryan Popple, CEO, Proterra, commented on the significance of the addition to their lineup:
“When Proterra originally introduced EV technology to the transit industry, we proved that EVs could compete with fossil fuel vehicles, and replace diesel buses in most cities. But we didn’t stop there. We continued to innovate, and today we’re announcing a drivetrain that completely outperforms an internal combustion diesel or CNG engine in every major performance category – efficiency, reliability, acceleration, hill climb and passenger-carrying power. In transit, state-of-the-art vehicle performance is now defined by EV technology like our new DuoPower driveline. For fleet customers that want the very best speed, power, energy efficiency and reliability – EV is the answer.”
Proterra’s solutions were mainly used for city transit, but the more powerful powertrain will enable them to venture into the coach business.
They are partnering with major Belgium-based bus manufacturer Van Hool to release new CX45E and CX35E coach models, based on their existing diesel buses, using Proterra’s new powertrain technology.
Filip Van Hool, CEO of Van Hool, commented
“Van Hool is truly excited and proud to partner up with Proterra, a pioneering company in the development and production of battery technology. The diesel CX45 coach has a proven track record and has become a benchmark coach in its own right in the industry. Integrating Proterra’s proven battery technology in the CX will take this coach to the next level. It is a clear statement as to Van Hool’s long-term commitment to the North American coach market and a testament to Van Hool’s responsiveness to the overall demand for zero-emission vehicles at large and over-the-road coaches in particular.”
They expect the first buses to be ready for deliveries in 2019.

About the Author

Fred Lambert's favorite gear

Sunday, October 8, 2017

From Nasa. Mercury blasted by meteors

Sept. 29, 2017

Small Collisions Make Big Impact on Mercury’s Thin Atmosphere


Mercury, our smallest planetary neighbor, has very little to call an atmosphere, but it does have a strange weather pattern: morning micro-meteor showers.
Recent modeling along with previously published results from NASA’s MESSENGER spacecraft — short for Mercury Surface, Space Environment, Geochemistry and Ranging, a mission that observed Mercury from 2011 to 2015 — has shed new light on how certain types of comets influence the lopsided bombardment of Mercury’s surface by tiny dust particles called micrometeoroids. This study also gave new insight into how these micrometeoroid showers can shape Mercury’s very thin atmosphere, called an exosphere.
The research, led by Petr Pokorný, Menelaos Sarantos and Diego Janches of NASA’s Goddard Space Flight Center in Greenbelt, Maryland, simulated the variations in meteoroid impacts, revealing surprising patterns in the time of day impacts occur. These findings were reported in The Astrophysical Journal Letters on June 19, 2017.
“Observations by MESSENGER indicated that dust must predominantly arrive at Mercury from specific directions, so we set out to prove this with models,” Pokorný said. This is the first such simulation of meteoroid impacts on Mercury. “We simulated meteoroids in the solar system, particularly those originating from comets, and let them evolve over time.”
Earlier findings based on data from MESSENGER’s Ultraviolet and Visible Spectrometer revealed the effect of meteoroid impacts on Mercury’s surface throughout the planet’s day. The presence of magnesium and calcium in the exosphere is higher at Mercury’s dawn — indicating that meteoroid impacts are more frequent on whatever part of the planet is experiencing dawn at a given time.
four images of Mercury
Scientists used models along with earlier findings from the MESSENGER mission to shed light on how certain types of comets influence the micrometeoroids that preferentially impact Mercury on the dawn side of the planet. Here, data from the Mercury Atmosphere and Surface Composition Spectrometer, or MASCS, instrument is overlain on the mosaic from the Mercury Dual Imaging System, or MDIS.
Credits: NASA/Johns Hopkins University Applied Physics Laboratory/Carnegie Institution of Washington
This dawn-dusk asymmetry is created by a combination of Mercury’s long day, in comparison to its year, and the fact that many meteroids in the solar system travel around the Sun in the direction opposite the planets. Because Mercury rotates so slowly — once every 58 Earth days, compared to a Mercury year, a complete trip around the Sun, lasting only 88 Earth days — the part of the planet at dawn spends a disproportionately long time in the path of one of the solar system’s primary populations of micrometeoroids. This population, called retrograde meteoroids, orbits the Sun in the direction opposite the planets and comprises pieces from disintegrated long-period comets. These retrograde meteroids are traveling against the flow of planetary traffic in our solar system, so their collisions with planets — Mercury, in this case — hit much harder than if they were traveling in the same direction.
These harder collisions helped the team further key in on the source of the micrometeoroids pummeling Mercury’s surface. Meteroids that originally came from asteroids wouldn’t be moving fast enough to create the observed impacts. Only meteoroids created from two certain types of comets — Jupiter-family and Halley-type — had the speed necessary to match the obseravations.
“The velocity of cometary meteoroids, like Halley-type, can exceed 224,000 miles per hour,” Pokorný said. “Meteoroids from asteroids only impact Mercury at a fraction of that speed.”
Jupiter-family comets, which are primarly influenced by our largest planet’s gravity, have a relatively short orbit of less than 20 years. These comets are thought to be small pieces of objects originating in the Kuiper Belt, where Pluto orbits. The other contributor, Halley-type comets, have a longer orbit lasting upwards of 200 years. They come from the Oort Cloud, the most distant objects of our solar system — more than a thousand times farther from the Sun than Earth.
The orbital distributions of both types of comets make them ideal candidates to produce the tiny meteoroids that influence Mercury’s exosphere.
Pokorný and his team hope that their initial findings will improve our understanding of the rate at which comet-based micrometeoroids impact Mercury, further improving the accuracy of models of Mercury and its exosphere.
Related:

By Kathryn DuFresne
NASA’s Goddard Space Flight Center, Greenbelt, Md.
Last Updated: Sept. 29, 2017
Editor: Rob Garner
Parker Solar Probe
Oct. 3, 2017

Parker Solar Probe Gets Visit From Namesake


Eugene N. Parker, professor emeritus at the University of Chicago, today visited the spacecraft that bears his name: NASA’s Parker Solar Probe. This is the first NASA mission that has been named for a living researcher, and is humanity’s first mission to the Sun.
Parker proposed the existence of the constant outflow of solar material from the sun, which is now called the solar wind, and theorized other fundamental stellar science processes. On Oct. 3, 2017, he viewed the spacecraft in a clean room at the Johns Hopkins Applied Physics Laboratory in Laurel, Maryland, where the probe was designed and is being built. He discussed the revolutionary heat shield and instruments with the Parker Solar Probe team and learned how the spacecraft will answer some of the crucial questions Parker identified about how stars work.
NASA’s Parker Solar Probe is scheduled for launch on July 31, 2018, from Cape Canaveral Air Force Station, Florida. The spacecraft will explore the Sun’s outer atmosphere and make critical observations that will answer decades-old questions about the physics of stars. The resulting data will also improve forecasts of major eruptions on the sun and subsequent space weather events that impact life on Earth, as well as satellites and astronauts in space.
Parker Solar Probe in APL clean room
Eugene Parker, professor emeritus at the University of Chicago, visiting the spacecraft that bears his name, NASA’s Parker Solar Probe, on Oct. 3, 2017. Engineers in the clean room at the Johns Hopkins Applied Physics Laboratory in Laurel, Maryland, where the probe was designed and is being built point out the instruments that will collect data as the mission travels directly through the Sun’s atmosphere.
Credits: NASA/JHUAPL
Parker Solar Probe in APL clean room
Eugene Parker (center), professor emeritus at the University of Chicago, visits the spacecraft that bears his name: NASA’s Parker Solar Probe. Thomas Zurbuchen (bottom right), the associate administrator for NASA’s Science Mission Directorate, and Ralph Semmel (behind Parker), the director for the Johns Hopkins Applied Physics Laboratory in Laurel, Maryland, where the probe was designed and is being built, joined the tour.
Credits: NASA/JHUAPL
Parker Solar Probe in APL clean room
Nicola Fox (bottom left), project scientist for NASA’s Parker Solar Probe at the Johns Hopkins Applied Physics Laboratory in Laurel, Maryland, describes the mission to the scientist for whom it’s named: Eugene Parker (middle). Eugene Parker first proposed the existence of the constant outflow of solar material from the sun — now called the solar wind — through which the spacecraft will travel. The red frame on the end of the spacecraft is a stand-in for the mission’s thermal protection system, which will reach temperatures of 2,500 degrees F during its journey.
Credits: NASA/JHUAPL
Parker Solar Probe in APL clean room
Eugene Parker, professor emeritus at the University of Chicago, visits the spacecraft that bears his name, NASA’s Parker Solar Probe, at the Johns Hopkins Applied Physics Laboratory in Laurel, Maryland, where the probe was designed and is being built. The spacecraft is humanity’s first mission to a star — it will travel directly through the Sun’s atmosphere.
Credits: NASA/JHUAPL
Last Updated: Oct. 3, 2017
Editor: Rob Garner
Tags:  Goddard Space Flight Center, Parker Solar Probe, Solar System, Sun

Tuesday, October 3, 2017

OUR INTERNATIONAL INDEX OF BEST WEB SITES. IF SOME LINKS DON'T WORK, TRY COPYING AND PASTING DIRECTLY INTO GOOGLE. THIS WEEK WE CELEBRATE HIGH INTELLIGENCE! I RECOMMEND YOU START FROM THE BOTTOM OF THE LIST AND CLICK UP TO THE TOP OF THE LIST 

1.=   HTTP://WWW.FREECHESS.ORG  </>

2. =  HTTP://WWW.NETFLIX.COM/WIHOME </>

5.=  https://www.youtube.com/watch?v=j5fU8wjdYhc  Great comedy movies.
24.=  https://plus.google.com/u/0/                           
25.=   https://www.nasa.gov/image-feature/goddard/coronal-hole-front-and-center                        
30.=  http://www.iTooch.com </> 31. = http://www.Netmaths.com </> 32. = http://www.Evernote.com</>
33. = http://www.abmaths.com</> 34. = http://www.Sciences.com</> 35. =
36. = http://www.human4us2.blogspot.ca      37. = https://plus.google.com/u/0/ </>
38.=  http://www.jaccorde.com</>
39.=  http://www.Atlasdumonde.com </> 40.= http://www.Echecs.com </>
46.=  http://www http://www.overviewinstitute.org/                                  
49.=  http://eol.org/ </>
55.=  https://en.wikipedia.org/wiki/Street_lighthttps://en.wikipedia.org/wiki/Street_light
62.= http://hyperphysics.phy-astr.gsu.edu/hbase/hframe.html      (For the super intelligent.)
64.= https://www.youtube.com/watch?v=iFDe5kUUyT0   (The secret of money.)
65 = https://www.youtube.com/watch?v=kMANwvYtx8sh  (Subtle influences on the human brain.)
66.= https://singularityhub.com

Neuroscience with Corina Marinescu




Parkinson’s disease in a dish: Researchers reproduce brain oscillations that characterize the disease
Abnormal oscillations in neurons that control movement, which likely cause the tremors that characterize Parkinson’s disease, have long been reported in patients with the disease. Now, University at Buffalo researchers working with stem cells report that they have reproduced these oscillations in a petri dish, paving the way for much faster ways to screen for new treatments or even a cure for Parkinson’s disease.

The paper is published online in Cell Reports.

“With this new finding, we can now generate in a dish the neuronal misfiring that is similar to what occurs in the brain of a Parkinson’s patient,” said Jian Feng, PhD, senior author on the paper and professor in the Department of Physiology and Biophysics in the Jacobs School of Medicine and Biomedical Sciences at UB. “A variety of studies and drug discovery efforts can be implemented on these human neurons to speed up the discovery of a cure for Parkinson’s disease.”

The work provides a useful platform for better understanding the molecular mechanisms at work in the disease, he added.

Source & further reading:
http://www.buffalo.edu/news/releases/2017/05/002.html

Journal article:
https://www.ncbi.nlm.nih.gov/pubmed/28467897

Image via UCSB (University of California Santa Barbara)

#parkinson'sdisease #dopamine #oscillations #dopaminergicneurons #neuroscience
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Pinterest. How to unlock your creative genius.

21 Ways to Get Inspired (Infographic)
Save this infographic for times when your muse could use a little boost.
Published June 14, 2016
Written by Linda Lacina


Terrence Alexander

21 Ways to Get Inspired (Infographic)

Saturday, September 30, 2017

Will they ever begin to do what is right for Canadians?

Will the New Democratic Party or the Liberal Party or the Conservative party of Canada do what is best for Canadians?


Joseph Raglione human4usbillions@gmail.com

1:00 AM (2 minutes ago)
to Robert
I can help you win your election but not with money.
Invite people into your party free of charge and listen to their ideas.
List the best ideas and publicize them across Canada.
For examples:
1.Bring Dentists into the Medicare programs and help millions of Canadians save their teeth without emptying their bank accounts.
2. Allow generic drugs to be sold across Canada.
3. Create Green schools across Canada and teach children to grow vegetables within the school classrooms and within the school buildings. Hungry children will learn to feed themselves and learn important life secrets at the same time. Find Stephen Fritz and his Green Machines  in New York and he will provide you with full instructions.
4. Create one standard for Electric Car charging stations across Canada and create a government commission to run the stations. All Electric cars sold in Canada must adhere to the standard and the government can charge a small fee for using the stations. In other words, the Canadian government can own and operate the system with funds going back into the government.
Slowly remove gas burning cars from the open market. Fossil fuels are dangerous polluters and only the selfish and ignorant continue to drive these vehicles.
Thanks for reading.

Sunday, September 24, 2017

New hope for failing lung victims from Shelly Fan at Singularity.

intact-lung-epithelial-cells-vascular-cells

This Radical New Method Regenerates Failing Lungs With Blood Vessels Intact


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Save for the occasional burning pain that accompanies a run, most people don’t pay much attention to the two-leafed organ puffing away in our chests.
But lungs are feats of engineering wonder: with over 40 types of cells embedded in a delicate but supple matrix, they continuously pump oxygen into the bloodstream over an area the size of a tennis field. Their exquisite tree-like structure optimizes gas exchange efficiency; unfortunately, it also makes engineering healthy replacement lungs a near-impossible task.
Rather than building lungs from scratch, scientists take a “replace and refresh approach”: they take a diseased lung, flush out its sickly, inflamed cells and reseed the empty matrix with healthy ones.
It’s an intricate procedure—nevertheless, the delicate branches of blood vessels are often completely destroyed during the process. Without blood to deliver nutrients and molecules to the newly seeded cells, the graft fails.
What if, thought Dr. Gordana Vunjak-Novakovic at Columbia University, rather than removing all cells from a donor lung, we gently clean out only the diseased cells in the airway without touching blood circulation?
This week, Vunjak-Novakovic’s team published a “radically new approach” to bioengineering lungs: making scaffolds with blood vessels intact.
When researchers added back therapeutic human cells that line the lung’s airways to a rat lung scaffold, the foreign cells—in this case, epithelium cells—homed to the correct location, attached, and thrived.
Because lung failure often stems from diseased epithelium cells, says study author Dr. N. Valerio Dorrello, this new method allows us to regenerate lungs by treating just the injured cells.
Dr. Matthew Bacchetta, who also worked on the project, sees the method as a “transformative” way to obtain lungs ready for transplant. Because lungs are notoriously bad at repairing themselves, in severe cases the only real option is a transplant.

injured-lung-epithelium-removal-vasculature-preservation-repopulation-therapeutic-cells
Image Credit: N. Valerio Dorrello and Gordana Vunjak-Novakovic, Columbia University
It’s a hard sell—only up to 20 percent of patients are still alive ten years later, the procedure is expensive, and the demand for donor lungs far exceeds the supply.
These new “vascularized” lungs bring us one step closer to the penultimate goal: transplanting lungs made from a patient’s own cells, seeded onto a donor scaffold from a cadaver or even primate or pig.
The patients’ cells give the scaffold a complete immune makeover, lowering the risk of immune rejection—a main reason why transplants fail.
“As a lung transplant surgeon, I am very excited about the great potential of our technique,” he says.

First Breath

Engineering functional lungs is nothing short of a moonshot, even in the ambitious field of regenerative medicine.
The lung is a real jungle: at the microscopic level, the tree-like airways contain alveoli, tiny bubble-like structures where the lungs exchange gas with our blood. Both arteries and veins enwrap the alveoli like two sets of mesh pockets.
At least a half dozen cellular denizens work in tandem to keep the alveoli spheres inflated, to guard the organ against infections, and to enforce the structure of its many branches.
This three-dimensional complexity is why we ruled out the possibility of growing lungs from scratch, explains Dr. Laura Niklason, a biomedical engineer at Yale University who was not involved in the new study.
Back in 2010, Niklason had a brilliant idea: rather than relying on synthetic templates that mimic the organ’s intricate structure—a “very tall order,” she says—scientists could use nature’s own template, the lung’s matrix, as a jumping off point.
Niklason’s approach is similar to stripping down a house to its bare bones—weight-bearing beams, struts and bolts—and reworking the rest to its new owner’s tastes.
As a proof-of-concept, Niklason’s team used a detergent that washed away the cells and blood vessels from a rat lung. They then soaked the lung matrix scaffold inside a “bioreactor” that mimics the conditions of a growing fetus.
When the team reseeded the scaffold with a cocktail of cells, the lung regrew its blood vessels, alveoli and tiny airways with the right types of cells—all within four days.
In the ultimate test of functionality, Niklason’s team transplanted the regrown lungs back into living rats. A few seconds later, the lung inflated, turning bright red as it took in oxygen and blood supply.
It’s just an initial step, the team wrote at the time. The lungs only survived up to two hours in the donor’s body, and subsequent analysis revealed bleeding and blood clots within the airway and regrown capillaries.
One potential reason is this: the blood vessels may not have formed proper junctions with the alveoli. While still allowing gas exchange, this eventually causes blood leaks into the lungs.

Breath of Fresh Air

If newly-grown blood vessels form malfunctioned junctions, why not preserve the originals instead?
That’s exactly what Vunjak-Novakovic’s team tackled in the new study published in Science Advances.
Adapting Niklason’s technique, the team inserted a tube into the airway of a newly harvested rat lung and pumped through a gentle detergent that only removed the lung’s epithelial cells—the inner lining.
Blood vessels, in contrast, were washed with an electrolyte solution similar to Gatorade.
With this small change, we removed over 70 percent of epithelial cells—which are often the root of lung diseases—but maintained the vasculature, the authors say.
Like cartographers mapping a new land, the team next probed the integrity of the vessels. Injecting tiny beads that glow under UV light into the lung’s main artery, they watched as the beads flooded the twisting capillaries, glowing bright within the larger vessels.
In contrast, there were no obvious signs of glowing beads within the airway or alveoli, suggesting that the blood vessels were intact—no leakage!
With scaffold in hand, the team next marinated the structure with human lung epithelium cells. As a bonus, they also used lung cells derived from induced pluripotent stem cells (iPSCs). iPSCs are made from a patient’s own cells—often skin cells—and can be coaxed to become nearly any other cell type with the right cocktail of signals.
Because iPSCs retain the person’s immune profile, scaffolds seeded with these cells have a much lower chance of being rejected.
Within a mere 24 hours, the team detected signs of the newly seeded cells within the lung scaffolds. Under the microscope, the newcomers attached to the right spot, stabilized and begun rapidly dividing to repopulate the missing cells.
The lung grafts also had a boost in breathing power—they could expand more fully—gaining back roughly 50 percent of what was lost during the detergent treatment.

A Breath Away?

The study stops short at the final test: transplanting the engineered lung back into a recipient. As with older generation scaffolds, the newly minted lungs could also develop deadly blood clots or bleeding once reintroduced into a living, breathing animal.
What’s more, the team only used a mild detergent in their preparation to preserve the lung’s integrity. The result was a partial cleanout with some of the rats’ own epithelial cells still intact.
These injured stragglers may provide important information to the new, healthy cells, so this could be an unexpected bonus, the authors explain. Whether they are friend or foe will have to be tested in a future study.
The technology needs a lot more work before it could be used in humans, but Vunjak-Novakovic and colleagues are already excited about potential new treatment options.
This study provides proof-of-concept evidence that our approach works, the authors write. We show, for the first time, that it’s possible to wash out diseased lung epithelial cells without touching blood vessels.
What really gets the team excited is this: although freshly harvested rat lungs were used in this study, in theory the method could be used without removing the lung.
This is “transformative:” patients with injured lung epithelial cells could be irrigated with the detergent to remove the sickly cells. Doctors can then harvest their skin cells and transform them into healthy lung cells to reseed the lung.
“Every day, I see children in intensive care with severe lung disease who depend on mechanical ventilation support,” says Dorrello. We may be on our way to an entirely new treatment solution for these patients and regenerate their broken lungs, he says.
Image Credit: N. Valerio Dorrello and Gordana Vunjak-Novakovic, Columbia University
Shelly Xuelai Fan is a neuroscientist at the University of California, San Francisco, where she studies ways to make old brains young again. In addition to research, she's also an avid science writer with an insatiable obsession with biotech, AI and all things neuro. She spends her spare time kayaking, bike camping and getting lost in the woods.

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